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. 2021 Feb 7;64(4):1856–1872. doi: 10.1021/acs.jmedchem.0c01886

Figure 9.

Figure 9

Hulahalla (4-year old female thoroughbred), shown above, before (left) and after (right) a five-day treatment of once daily t-TUCB at 0.1 mg/kg. Hulahalla presented with acute laminitis and was treated with standard of care for 3 days with little effect. Her condition became extremely painful, and given the lack of response to the medications and worsening of the condition, humane euthanasia was being considered as the last resort to relieve pain and suffering. At this point, daily t-TUCB was administered in addition to her standard of care treatment. Over the course of the five-day treatment, her pain level decreased, and no signs of adverse effects were observed both from clinical exams and evaluation of blood work. Hulahalla continued to do well, and laminitis has not reoccurred.