Table 1. Physical Properties, Potency, and Target Occupancy of AR9281, TPPU, EC5023, EC5024, and EC5026.
Solubility was measured with sodium phosphate buffer (0.1 M, pH 7.4).
LogP was measured by HPLC.
Ki and tR (which is a reciprocal of koff) were determined against the affinity purified recombinant human sEH (hsEH) by a FRET-displacement assay.