Table 1. Physical Properties, Potency, and Target Occupancy of AR9281, TPPU, EC5023, EC5024, and EC5026.

^aSolubility was measured with sodium phosphate buffer (0.1 M, pH 7.4).

^bLogP was measured by HPLC.

^cK_i and t_R (which is a reciprocal of k_off) were determined against the affinity purified recombinant human sEH (hsEH) by a FRET-displacement assay.