Table 1.
Description and details of all genes and proteins of the SARS-CoV-2.
(a) The description and division of regions of a complete SARS-CoV-2 genome (reference genome nc-045512 from the GenBank).
(b) This table shows the location and number of amino acids for each gene/protein {the first gene ORF1ab expresses a polyprotein comprised of 16 nonstructural proteins (NSP's) shown in (c)}.
(c) The 16 NSP's {nonstructural proteins} from the SARS-CoV-2 polyprotein.
| (a) | |||||
|---|---|---|---|---|---|
|
NC_045512.2 29903 nt | |||||
| Start | Stop | Gene symbol | Strand | NCBI gene ID | |
| 1 | 266 | 21555 | ORF1ab | Plus | 43740578 |
| 2 | 21563 | 25384 | S | Plus | 43740568 |
| 3 | 25393 | 26220 | ORF3a | Plus | 43740569 |
| 4 | 26245 | 26472 | E | Plus | 43740570 |
| 5 | 26523 | 27191 | M | Plus | 43740571 |
| 6 | 27202 | 27387 | ORF6 | Plus | 43740572 |
| 7 | 27394 | 27759 | ORF7a | Plus | 43740573 |
| 8 | 27756 | 27887 | ORF7b | Plus | 43740574 |
| 9 | 27894 | 28259 | ORF8 | Plus | 43740577 |
| 10 | 28274 | 29533 | N | Plus | 43740575 |
| 11 | 29558 | 29674 | ORF10 | Plus | 43740576 |
| (b) | |||||
|---|---|---|---|---|---|
| Gene | Number (#) | Gene | Gene ID | Location | Protein |
| 1 | 1 (7096) | ORF1ab | 43740578 | 266–21555 | ORF1ab polyprotein |
| 1 | 1 (4405) | ORF1a | 43740578 | 266–13483 | ORF1a polyprotein |
| 2 | 2 (1273) | ORF2 (S) | 43740568 | 21563–25384 | Spike protein (S protein) |
| 3 | 3 (275) | ORF3a | 43740569 | 25393–26220 | ORF3a protein |
| 4 | 4 (75) | ORF4 (E) | 43740570 | 26245–26472 | Envelope protein (E protein) |
| 5 | 5 (222) | ORF5 (M) | 43740571 | 26523–27191 | Membrane protein (M protein) |
| 6 | 6 (61) | ORF6 | 43740572 | 27202–27387 | ORF6 protein |
| 7 | 7 (121) | ORF7a | 43740573 | 27394–27759 | ORF7a protein |
| 8 | 8 (43) | ORF7b | 43740574 | 27756–27887 | ORF7b protein |
| 9 | 9 (121) | ORF8 | 43740577 | 27894–28259 | ORF8 protein |
| 10 | 10 (419) | ORF9 (N) | 43740575 | 28274–29533 | Nucleocapsid phosphoprotein (N protein) |
| 11 | 11 (38) | ORF10 | 43740576 | 29558–29674 | ORF10 protein |
| (c) | ||||
|---|---|---|---|---|
| # | Name | Accession | Amino acids | Proposed function |
| (i) | NSP1 | YP_009725297.1 | 180 amino acids | Induce host mRNA (leader protein) cleavage |
| (ii) | NSP2 | YP_009725298.1 | 638 amino acids | Binds to PHBs 1, 2 |
| (iii) | NSP3a | YP_009725299.1 | 1945 amino acids | Release NSPs 1, 2, 3 (Papain like proteinase) |
| (iv) | NSP4 | YP_009725300.1 | 500 amino acids | Membrane rearrangement |
| (v) | NSP5a | YP_009725301.1 | 306 amino acids | Cleaves at 11 sites of (3C-like proteinase) NSP polyprotein |
| (vi) | NSP6 | YP_009725302.1 | 290 amino acids | Generates autophagosomes |
| (vii) | NSP7 | YP_009725303.1 | 83 amino acids | Dimerizes with NSP8 |
| (viii) | NSP8 | YP_009725304.1 | 198 amino acids | Stimulates NSP12 |
| (ix) | NSP9 | YP_009725305.1 | 113 amino acids | Binds to helicase (?) |
| (x) | NSP10 | YP_009725306.1 | 139 amino acids | Stimulates NSP16 (?) |
| (xi) | NSP11 | YP_009725312.1 | 13 amino acids | Unknown |
| (xii) | NSP12a | YP_009725307.1 | 932 amino acids | Copies viral RNA (RNA polymerase) methylation (guanine) |
| (xiii) | NSP13 | YP_009725308.1 | 601 amino acids | Unwinds duplex RNA (helicase) |
| (xiv) | NSP14 | YP_009725309.1 | 527 amino acids | 5′-cap RNA (3′ to 5′ exonuclease, guanine N7-methyltransferase) |
| (xv) | NSP15a | YP_009725310.1 | 346 amino acids | Degrade RNA to (endoRNAse/endoribonuclease) evade host defense |
| (xvi) | NSP16 | YP_009725311.1 | 298 amino acids | 5′-cap RNA (2′-O-ribose-methyltransferase—potential antiviral drug target) methylation (adenine) |