Figure 4.
Virus-encoded OX40L and CD40L improve anti-tumor efficacy and induce robust infiltration of tumor-specific CD8+ T cells into the tumor in a syngeneic mouse model of B16.OVA melanoma
(A) 1 × 109 VP of PeptiCRAd Ad5/3-D24-OVA or PeptiCRAd VALO-mD901-OVA was given intratumorally 6, 8, and 20 days post-tumor implantation. Average tumor growth curves for all treatment groups are shown. (B) Immunological analysis of tumors and tumor-draining lymph nodes of treated mice. Lymph nodes from all mice from each treatment group were pooled in order to get enough cells for the flow cytometric analysis. The number of mice in the mock group was 7 and in both PeptiCRAd groups, was 10. Statistical analysis was performed with one-way ANOVA. ∗p < 0.05, ∗∗p < 0.01.