Fig. 4.

In vivo distribution of CXCR4⁺hybrid NPs. A) Biophotonic images of the organ distribution 4h after intravenous injection of PBS, Cy5, Cy5 labeled liposomes and Cy5-labeled hybrid NPs, with various exosome-liposome ratios. B) Representative fluorescence microscopic images of the femur 1, 2, and 4 h after injection of Cy5-labeled CXCR4⁺ hybrid NPs (exosomes-liposomes ratio = 1:1; scale bars on the left, upper right, and bottom right represent 500 μm, 100 μm and 20 μm, respectively).