Figure 2. Non‐neutralising anti‐N antibodies reduce viraemia but require TRIM21.

• A, B
  Wild‐type (WT) and TRIM21 knockout (KO) mice were infected with 0.5 × 10⁵ FFU LCMV clone 13 (6 mice per group) and either received anti‐N mAb KL53 (+) or control (−) intraperitoneally on days 1 and 3pi. Two mice were uninfected (UI). (A) Weights were monitored throughout infection, with final day 8 weights of individual mice presented separately. (B) Viral titres in the spleen, liver, lung and kidney of all mice were determined by FFA day 8pi. Each data point represents one mouse, with results from two repeat experiments combined.

Data information: All data are presented as mean with standard error, **P < 0.01, ***P < 0.001, NS not significant, unpaired t‐test.