Table 1.
Genotypes and phenotypes of cell death mediator mutations
| Genotype | Phenotype |
|---|---|
| Casp8C362A/C362A | Embryonic lethal (E12.5) |
| Casp8C362A/C362A Mlkl −/− | Perinatal lethal |
| Casp8C362A/C362A Ripk3 −/− | 75% of animals survive past weaning |
| Casp8C362A/C362A Mlkl −/− Ripk1 −/− | Lethal before weaning |
| Casp8C362A/C362A Mlkl −/− Asc −/− | 65% of animals survive past weaning |
| Casp8C362A/C362A Mlkl −/− Casp1 −/− | 40% of animals survive past weaning |
| Casp8C362A/C362A Mlkl −/− Casp1 −/− Casp11 −/− | 75% of animals survive past weaning |
| Casp8C362A/C362A Ripk3 −/− Casp1 −/− Casp11 −/− | Survival past weaning, best survival |
| Casp8C362S/C362S | Embryonic lethal (E12.5) |
| Casp8C362S/C362S Mlkl −/− | Perinatal lethal |
| Casp8C362S/C362S Mlkl −/− Casp1 −/− | Survival beyond parturition |
| Casp8C362S/C362S Mlkl −/− Asc −/− | Survival beyond parturition |
| Casp8D387A/D387A | No overt phenotype |
| Casp8D387A/D387A Mlkl −/− | Inflammatory phenotype |
| Casp8D387A/D387A Mlkl −/− Fasl+/ − | Rescues phenotype |
| Casp8D387A/D387A Mlkl −/− Ripk1+/ − | Rescues phenotype |
| Casp8D387A/D387A Mlkl −/− Fadd+/ − | Rescues phenotype |
| Casp8D387A/D387A Mlkl −/− Fadd −/− | Lethal before weaning |
| Casp8D387A/D387A Mlkl −/− Fadd −/− Ripk1 −/− | Survival past weaning |
| Casp8D387A/D387A Mlkl −/− Fadd −/− Casp1 −/− | Survival past weaning |
| Casp8IEC‐KO | Ileitis |
| Casp8IEC‐KO Mlkl −/− | Rescues phenotype |
| FaddIEC‐KO | Colitis and ileitis |
| FaddIEC‐KO Ripk3 −/− | Rescues phenotype |
| FaddIEC‐KO Ripk3IEC‐KO | Rescues phenotype |
| FaddIEC‐KO Mlkl −/− | Casp8‐driven pathology |
| FaddIEC‐KO Mlkl −/− ASC −/− | Casp8‐driven pathology |
| FaddIEC‐KO Mlkl −/− Gsdmd −/− | Rescues phenotype |
Summary of genotypes and main associated phenotypes discussed in the context of crosstalk between different cell death pathways. Please refer to the original publications for a complete list of crosses and their respective phenotypes. References for listed genotypes are indicated throughout the text.