Figure 1.

Alternative splicing in the neural retina. (A) Common mechanisms of alternative splicing in the retina. Boxes represent exons, lines represent introns, promoters are represented with arrows and polyadenylation sites are indicated with -AAAA. Exon regions included in the alternative transcript are colored. (B) Microexons have a role in late neurogenesis and are relevant in neurological disorders. The reduced expression of neural-specific splicing factors that regulate the inclusion of microexons is linked to the altered splicing of microexons in patients with neurological disorders. (C) Novel alternative splicing events in the human retina detected by RNA sequencing (data from [35]).