Table 1.
Metabolite levels significantly different between control and treated U87IDHmut tumors at D5 ± 1.
| Metabolite | Cramer-Rao Lower Bounds (%) | Concentration (AU) | ||||
|---|---|---|---|---|---|---|
| Control | AG-881 | BAY-1436032 | Control | AG-881 | BAY-1436032 | |
| 2HG | 8 | 22 | 10 | 4.10 ± 0.17 | 1.73 ± 0.12 | 3.09 ± 0.12 |
| GSH | 4 | 5 | 4 | 4.72 ± 0.07 | 5.12 ± 0.08 | 4.26 ± 0.06 |
| NAA | 7 | 8 | 7 | 3.36 ± 0.13 | 4.97 ± 0.15 | 4.62 ± 0.13 |
| Lac | 5 | 7 | 6 | 15.04 ± 0.27 | - | 8.67 ± 0.25 |
| Glc | 30 | 28 | 22 | 1.12 ± 0.22 | - | 2.25 ± 0.12 |
| mI | 14 | 6 | 7 | 2.17 ± 0.07 | 2.97 ± 0.09 | 2.49 ± 0.07 |
| Asp | 7 | 13 | 5 | 6.53 ± 0.27 | 1.19 ± 0.12 | 14.35 ± 0.29 |
| Tau | 4 | 4 | 6 | 9.30 ± 0.15 | 8.04 ± 0.19 | 6.45 ± 0.14 |
| GABA | 6 | 9 | 7 | 7.30 ± 0.20 | 2.57 ± 0.14 | 3.87 ± 0.14 |
| Ala | 13 | 15 | 18 | 3.03 ± 0.10 | 1.09 ± 0.05 | 0.81 ± 0.04 |
| Gln | 6 | 21 | 8 | 3.15 ± 0.11 | 1.54 ± 0.09 | 1.74 ± 0.06 |
| Glu | 3 | 3 | 2 | 12.17 ± 0.17 | 17.35 ± 0.24 | 16.98 ± 0.17 |
| Gly | 7 | 13 | 7 | 7.20 ± 0.21 | 0.30 ± 0.04 | - |
| sI | 44 | 13 | 17 | 0.15 ± 0.03 | - | - |
| tCho | 1 | 1 | 1 | 9.78 ± 0.05 | 14.51 ± 0.07 | 10.31 ± 0.05 |
| tCr | 7 | 12 | 8 | 2.03 ± 0.06 | 1.53 ± 0.07 | 1.36 ± 0.05 |
| GLX | 3 | 3 | 2 | 16.47 ± 0.22 | 18.74 ± 0.25 | 19.08 ± 0.20 |