Table 2.
Metabolite levels significantly different between control and treated BT257 tumors at early (D7 ± 2) and late (D15 ± 1) time points.
| D7 ± 2 | ||||||
|---|---|---|---|---|---|---|
| Metabolite | Cramer-Rao Lower Bounds (%) | Concentration (AU) | ||||
| Control | AG-881 | BAY-1436032 | Control | AG-881 | BAY-1436032 | |
| 2HG | 6 | 7 | 5 | 8.63 ± 0.16 | 5.57 ± 0.13 | 6.89 ± 0.13 |
| GSH | 6 | 6 | 5 | 2.19 ± 0.04 | 2.34 ± 0.05 | 2.53 ± 0.05 |
| NAA | 4 | 4 | 3 | 8.54 ± 0.10 | 11.38 ± 0.10 | 13.44 ± 0.11 |
| Lac | 14 | 8 | 6 | 5.73 ± 0.22 | 4.48 ± 0.10 | 4.29 ± 0.11 |
| mI | 4 | 3 | 2 | 19.83 ± 0.14 | 15.27 ± 0.12 | 20.38 ± 0.13 |
| Asp | 22 | 28 | 7 | 6.30 ± 0.19 | 2.26 ± 0.13 | 7.75 ± 0.23 |
| Tau | 5 | 3 | 3 | 10.74 ± 0.13 | 14.16 ± 0.16 | 10.42 ± 0.13 |
| GABA | 5 | 12 | 4 | 12.64 ± 0.17 | 6.62 ± 0.14 | 13.28 ± 0.19 |
| Ala | 22 | 10 | 10 | 0.98 ± 0.05 | 1.66 ± 0.07 | - |
| Gln | 6 | 5 | 5 | 4.93 ± 0.08 | 4.55 ± 0.09 | 4.48 ± 0.08 |
| Glu | 7 | 4 | 4 | 7.59 ± 0.14 | 11.10 ± 0.14 | 11.22 ± 0.16 |
| Gly | 5 | 4 | 4 | 27.39 ± 0.35 | 21.03 ± 0.19 | 16.23 ± 0.15 |
| sI | 14 | 8 | 13 | 0.46 ± 0.02 | 0.66 ± 0.02 | 0.88 ± 0.03 |
| tCho | 1 | 1 | 1 | 12.70 ± 0.04 | 8.70 ± 0.04 | 9.31 ± 0.04 |
| tCr | 4 | 2 | 2 | 7.87 ± 0.06 | 12.13 ± 0.09 | 8.75 ± 0.07 |
| GLX | 5 | 4 | 3 | 13.19 ± 0.18 | 15.21 ± 0.20 | 16.39 ± 0.19 |
| D15 ± 1 | ||||||
| 2HG | 4 | 7 | 4 | 14.79 ± 0.20 | 4.73 ± 0.17 | 7.42 ± 0.17 |
| GSH | 11 | 7 | 4 | 3.41 ± 0.06 | 2.20 ± 0.07 | 1.89 ± 0.04 |
| NAA | 4 | 4 | 4 | 11.45 ± 0.10 | - | 8.73 ± 0.08 |
| Lac | 8 | 13 | 10 | 7.28 ± 0.19 | 5.94 ± 0.38 | 3.18 ± 0.17 |
| mI | 3 | 2 | 2 | 19.45 ± 0.11 | 22.92 ± 0.25 | 22.49 ± 0.17 |
| Asp | 9 | 10 | 6 | 8.44 ± 0.31 | 4.75 ± 0.24 | 6.49 ± 0.18 |
| Tau | 4 | 5 | 4 | 11.04 ± 0.12 | 15.38 ± 0.38 | 11.68 ± 0.17 |
| GABA | 4 | 6 | 5 | 20.74 ± 0.18 | 13.82 ± 0.37 | 8.48 ± 0.14 |
| Ala | 10 | 11 | 15 | 2.29 ± 0.06 | - | 1.00 ± 0.03 |
| Gln | 7 | 6 | 6 | 5.47 ± 0.10 | 3.90 ± 0.12 | 2.48 ± 0.07 |
| Glu | 5 | 7 | 4 | 7.12 ± 0.13 | 9.89 ± 0.31 | 10.83 ± 0.15 |
| Gly | 4 | 6 | 4 | 19.87 ± 0.15 | 13.32 ± 0.38 | 19.19 ± 0.17 |
| sI | 13 | 14 | 11 | 0.57 ± 0.03 | 0.81 ± 0.06 | 0.34 ± 0.02 |
| tCho | 1 | 1 | 1 | 12.37 ± 0.05 | 10.60 ± 0.06 | 11.45 ± 0.06 |
| tCr | 3 | 3 | 3 | 7.89 ± 0.06 | 10.79 ± 0.16 | 13.31 ± 0.11 |
| GLX | 4 | 5 | 4 | 12.03 ± 0.18 | 13.90 ± 0.34 | 14.91 ± 0.19 |