Table 3.
Metabolite levels significantly different between control and treated SF10417 tumors at early (D6 ± 2) and late (D14 ± 2) time points.
| D6 ± 2 | ||||||
|---|---|---|---|---|---|---|
| Metabolite | Cramer-Rao Lower Bounds (%) | Concentration (AU) | ||||
| Control | AG-881 | BAY-1436032 | Control | AG-881 | BAY-1436032 | |
| 2-HG | 4 | 5 | 5 | 7.73 ± 0.13 | 7.17 ± 0.11 | 5.98 ± 0.11 |
| GSH | 5 | 5 | 3 | 2.71 ± 0.05 | 1.73 ± 0.03 | 3.08 ± 0.04 |
| NAA | 4 | 3 | 3 | 6.37 ± 0.10 | 8.10 ± 0.06 | 8.57 ± 0.06 |
| Lac | 30 | 13 | 7 | 3.62 ± 0.19 | - | 3.13 ± 0.06 |
| Glc | 29 | 14 | 5 | 3.17 ± 0.20 | 3.98 ± 0.12 | 5.39 ± 0.12 |
| mI | 3 | 2 | 2 | 8.99 ± 0.07 | 7.00 ± 0.07 | 8.13 ± 0.04 |
| Asp | 6 | 5 | 5 | 11.37 ± 0.26 | - | 5.34 ± 0.12 |
| Tau | 5 | 4 | 3 | 5.27 ± 0.10 | 8.66 ± 0.08 | 13.07 ± 0.09 |
| GABA | 7 | 4 | 5 | 4.34 ± 0.11 | 6.75 ± 0.09 | 5.93 ± 0.09 |
| Ala | 36 | 11 | 10 | 0.47 ± 0.04 | - | 0.83 ± 0.03 |
| Gln | 16 | 6 | 4 | 1.71 ± 0.09 | 3.28 ± 0.07 | 2.67 ± 0.05 |
| Glu | 6 | 5 | 3 | 4.93 ± 0.10 | 5.92 ± 0.08 | 11.24 ± 0.09 |
| Gly | 5 | 3 | 5 | 12.68 ± 0.16 | 13.79 ± 0.11 | 10.25 ± 0.10 |
| sI | 30 | 13 | 10 | 0.29 ± 0.02 | 0.38 ± 0.03 | 0.18 ± 0.01 |
| tCho | 1 | 1 | 1 | 9.75 ± 0.04 | 7.99 ± 0.03 | 6.18 ± 0.03 |
| tCr | 3 | 2 | 2 | 9.77 ± 0.07 | 7.20 ± 0.05 | 8.03 ± 0.04 |
| GLX | 5 | 4 | 3 | 7.31 ± 0.15 | 11.48 ± 0.11 | 13.54 ± 0.11 |
| D14 ± 2 | ||||||
| 2-HG | 3 | 4 | 4 | 9.91 ± 0.16 | 6.56 ± 0.13 | 8.09 ± 0.12 |
| GSH | 5 | 5 | 5 | 1.71 ± 0.05 | 3.31 ± 0.06 | 2.62 ± 0.04 |
| NAA | 4 | 3 | 3 | 9.42 ± 0.17 | 6.01 ± 0.10 | 9.04 ± 0.08 |
| Lac | 7 | 15 | 7 | 2.43 ± 0.17 | - | - |
| Glc | 10 | 8 | 12 | 3.19 ± 0.18 | - | - |
| mI | 2 | 3 | 3 | 10.21 ± 0.09 | 9.72 ± 0.09 | 8.34 ± 0.07 |
| Asp | 6 | 7 | 7 | 15.89 ± 0.42 | 9.05 ± 0.32 | 5.50 ± 0.14 |
| Tau | 4 | 3 | 4 | 5.02 ± 0.12 | 7.46 ± 0.12 | 13.98 ± 0.13 |
| GABA | 8 | 5 | 5 | 4.71 ± 0.15 | - | 7.71 ± 0.12 |
| Ala | 16 | 42 | 17 | 0.96 ± 0.15 | - | - |
| Gln | 25 | 9 | 5 | 0.88 ± 0.09 | 1.74 ± 0.10 | 3.20 ± 0.06 |
| Glu | 6 | 3 | 6 | 5.26 ± 0.14 | 6.93 ± 0.10 | 7.63 ± 0.12 |
| Gly | 4 | 4 | 5 | 7.88 ± 0.19 | 14.64 ± 0.14 | 10.58 ± 0.17 |
| sI | 20 | 19 | 16 | 0.22 ± 0.03 | - | 0.32 ± 0.01 |
| tCho | 1 | 1 | 1 | 9.28 ± 0.05 | 8.89 ± 0.05 | 6.06 ± 0.03 |
| tCr | 3 | 2 | 2 | 7.41 ± 0.11 | 10.62 ± 0.10 | - |
| GLX | 6 | 3 | 4 | 5.98 ± 0.18 | 7.90 ± 0.12 | 11.69 ± 0.15 |