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. 2021 Feb 12;22(4):1828. doi: 10.3390/ijms22041828

Figure 3.

Figure 3

Atorvastatin inhibits radiation-induced JNK/c-Jun signaling. (A) Western blot analysis to determine JNK and p38 activation in control (Con), atorvastatin (Atorva)-treated, irradiated (IR), and IR + Atorva HUVECs. (B) Western blot analysis to confirm nuclear translocation of phosphorylated c-Jun. Cytoplasmic and nuclear extracts were separated, and western blot analysis was performed to evaluate translocation of phosphorylated c-Jun. (C) Immunofluorescence images and the fluorescence intensity of phosphorylated c-Jun. Representative images showing phosphorylated c-Jun (green) and DAPI (blue). Scale bars represent 100 μm. Data are presented as the mean± standard deviation of triplicate experiments. Images are representative of 3 independent experiments. * p < 0.05 vs. negative control (Con), # p < 0.5 vs. irradiated control (IR).