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. 2021 Feb 12;22(4):1828. doi: 10.3390/ijms22041828

Figure 6.

Figure 6

Atorvastatin mitigates the radiation-induced inflammatory response in vivo by inhibiting PAI-1 expression. (A) Small intestine and plasma PAI-1 levels in control (Con), irradiated (IR), and atorvastatin (Atorva)-treated IR (IR + Atorva) mice. Immunohistochemistry of (B) CD31 (an endothelial cell marker; Green) and phospho-JNK (Red), (C) CD68, a monocyte maker, and (D) myeloperoxidase (MPO), a neutrophil marker, in intestinal tissue. The yellow arrows indicate CD31-positive endothelial cells. (E) mRNA levels of (pro)-inflammatory cytokines Mmp9, Il1b, Tnfa, and Mcp1 in the intestinal tissue of Con, IR, and IR + Atorva groups. Data are presented as the mean ± standard deviation of the mean; n = 5 mice per group. * p < 0.05 compared to the Con group; # p < 0.05 compared to the IR group. Scale bars represent 50 μm.