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HMGA2 is regulated by the RAF kinase inhibitor protein (RKIP) pathway. RKIP suppresses HMGA2 expression directly, as well as indirectly, by inducing the miRNAs miR-185, miR-200, and miR-98, which target the 3′UTR of HMGA2 mRNA. Suppression of HMGA2 via RKIP and miRNAs reduces the expression of the EMT-promoting factors CCL5 and SDC2.
