Table 4.
Combination index (CI) of cisplatin/AZD2281 combined therapies. Top row: combined sequential (cisplatin>AZD2281) monotherapies (mono). Bottom row: concomitant administration of cisplatin and AZD2281 for 6 h, followed by AZD2281 monotherapy. Cisplatin (cisp) concentration was equal to the IC50 value; AZD2281 concentrations are indicated.
| GCT27 cis-r | 2102EP cis-r | ||
|---|---|---|---|
| [AZD2281] | CI | CI | |
| 6 h cisp IC50 + | 1 µM | 0.67 | 1.1 |
| AZD2281 | 2 µM | 0.28 | 0.93 |
| mono | 3 µM | 0.04 | 0.46 |
| 5 µM | 0.05 | 0.35 | |
| [AZD2281] | CI | CI | |
| 6 h cisp | 1 µM | 0.7 | 1 |
| IC50/AZD2281 | 2 µM | 0.58 | 0.85 |
| + AZD2281 | 3 µM | 0.19 | 0.79 |
| mono | 5 µM | 0.05 | 0.48 |