Figure 1.

Karyogram depicting the approximate locations of candidate PrCa risk loci reported through linkage, GWAS and sequencing study approaches. To the right of the chromosome ideogram, triangle symbols indicate the position of 269 reported independent GWAS index variants [127] and circle symbols the locations of DNA repair genes reported as a potential candidate for risk in two or more PrCa sequencing studies (listed within Table 1). To the left of the chromosome ideogram, line symbols show the approximate intervals of linkage peaks according to representative markers for the region or cytogenetic band co-ordinates. Grey coloured symbols indicate no or limited evidence for association with risk of aggressive PrCa, the black colour denotes moderate or conflicting evidence for risk of aggressive disease and black symbols with a red border signify stronger evidence for a contribution towards poorer prognosis phenotypes. The karyogram is overlaid with a heat map depicting gene density across the human genome in 1 Mb windows and was generated using RIdeogram [128] and custom plotting functions.