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The schematic diagram of PRRSV inhibition by TPP. On the one hand, TPP blocks the attachment, internalization, and release of PRRSV or inhibits the assembly of viral RTC after virions enter cells during the virus life cycle. On the other hand, TPP is capable of restraining PRRSV-induced translocation of NF-κB p65 into the nucleus, thereby suppressing the expression of cytokines, which may contribute to its inhibition of PRRSV.
