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. 2021 Feb 13;10(2):387. doi: 10.3390/cells10020387

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Different gene expression in mouse heart tissue following ²²Ti irradiation: (A) bar graphs showing differentially expressed genes in mouse heart tissue after exposure to different ²²Ti (Ti, titanium)-IR exposure. Colors in the diagram represent genes putatively affected by the following ²²Ti dose exposure: blue circles correspond to 3 cGy, green circles to 6.5 cGy, yellow circles to 13 cGy, and purple circles to 26 cGy. (B) Venn diagram depicting the number of differentially expressed genes in mouse hearts across different doses of Ti radiation exposure. Colors in the diagram represent genes putatively affected by the following Ti dose exposure: blue circles correspond to 3 cGy, green circles to 6.5 cGy, yellow circles to 13 cGy, and purple circles to 26 cGy. (C) Table depicting the number of up- and downregulated genes after exposure to different ²²Ti-IR doses in the heart tissue and (D–F) heat maps showing differentially expressed genes at different ²²Ti-IR doses. Relative expression values are indicated on the color key and increase in value from blue to red (n = 5/group).