Figure 2.

Schematic representation of vascular-related problems and countermeasures faced in the process of nanodrug penetration. (1) Intravascular transport: vascular irregularity and cumulative solid stress are resolved by normalization and decompression, respectively. (2) Trans-vascular transport: elevated interstitial fluid pressure (IFP) and limited endothelial space are improved by decreasing intertumoral IFP and increasing vascular permeability, respectively. Adapted from Yang et al. [115].