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Schematic representation of transmission and action in the microenvironment of large amounts of fibrin around colon tumors and their tissues. Compared with free tissue plasminogen activator (t-PA), using t-PA-assembled redox-active nanoparticles (T-PA@iRNP) can effectively relieve the compressed tumor vessels and upregulate blood perfusion, and improve the poor distribution of nanodrugs in tumors. Reproduced from Mei [134].
