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. 2021 Feb 14;22(4):1891. doi: 10.3390/ijms22041891

Figure 4.

Figure 4

Effects of nerve decompression on the CCI-induced changes of peptidergic and non-peptidergic terminals in dorsal horn. (A,D,G) On contralateral sides, peptidergic ((A) substance P (SP) and (D) calcitonin gene-related peptide (CGRP))- and non-peptidergic ((G) isolectin B4 (IB4))-ir expressions in primary afferent terminals were shown in the medial portion of dorsal horn at POW 8. SP-ir expression formed beaded particles mostly in lamina I and extended to the outer part of lamina II. CGRP-ir expression exhibited as dense varicosities in lamina I, the outer part of lamina II and even projected to lamina V. In contrast, IB4-ir expression displayed an irregular structure and expressed generally in the inner part of lamina II. On ipsilateral sides, (B,E,H) CCI and (C,F,I) Decompression groups revealed that CCI-induced SP- and IB4-ir expressions rather than CGRP-ir expression had an obvious increase in their corresponding laminae after nerve decompression (arrowheads in (C,I)). Scale bar = 50 μm.