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Processing of the endogenous S2 site cannot be induced by the stimulation of ADAM10 or ADAM17. (A) WT mEFs were treated with 25 ng/mL of PMA, a strong activator of ADAM17, or (B) with 2.5 µM ionomycin, which strongly activates both ADAM10 and 17, with 5 mM EDTA treatment for 30 min included as a positive control for the processing of Notch1. The Western blots shown are representative of at least 3 independent experiments.
