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. 2021 Feb 12;22(4):1846. doi: 10.3390/ijms22041846

Figure 7.

Figure 7

ADAMs 9, 12, and 19 can cleave N1-AP in A10/17-/- mEFs. Overexpression of ADAMs 9, 12, 15, 17, and 19 in A10/17-/- mEFs shows that all but ADAM15 can increase the processing of N1-AP compared to the catalytically inactive ADAM17E>A control. Data are shown as mean ± SEM for n ≥ 3 independent experiments (n = 3 for ADAM17E>A mutant, n = 6 for all other samples). * indicates p < 0.05 using the unpaired 2-tailed Student’s t-test. The difference between the control sample, in which only N1-AP was expressed, and the sample in which the inactive ADAM17E>A was co-expressed with N1-AP was not statistically significant (not indicated on the figure), and the difference between N1-AP shedding in the presence of overexpressed inactive ADAM17E>A and ADAM15 also did not reach statistical significance (n.s.).