Table 1.
The list of reported miR-7 regulators in cancer.
I. Transcriptional Level | ||||
---|---|---|---|---|
Transcription Factors | MIR7-1 | MIR7-2 | MIR7-3 | References |
c-Myc | ↑ | — | — | [46] |
HOXD10 | ↑ | — | — | [47] |
HNF4 α | — | ↑ | — | [48] |
FOXP3 | ↑ | ↑ | — | [49] |
RELA | ↓ | ↓ | — | [50,51,52] |
Usp18 | ↓ | ↓ | ↓ | [53] |
II. Post-Transcriptional Level | ||||
pri-miRNA | ||||
Factor | pri-miR-7-1 | pri-miR-7-2 | ||
HuR/MSI2 | ↑ | — | — | [54] |
QKI-5 | ↓ | — | — | [55] |
QKI-6 | ↓ | — | — | [55] |
SF2/ASF | ↑ | — | — | [56] |
Mature miRNA Level | ||||
ceRNA | Regulation | Confirmed in: | ||
circRNA | ||||
ciRS-7 | ↓ | brain, non-small cell lung cancer, esophageal squamous cell carcinoma, papillary thyroid cancer, colorectal cancer | [59,60,61,62,63] | |
circSNCA | ↓ | brain | [64] | |
circ_0006528 | ↓ | breast cancer | [65,66] | |
circ-U2AF1 | ↓ | glioma | [67] | |
circ_0000735 | ↓ | prostate cancer | [68] | |
circ-ITCH | ↓ | osteosarcoma | [69] | |
circ-TFCP2L1 | ↓ | breast cancer | [70] | |
circ_0015756 | ↓ | hepatocellular carcinoma | [71] | |
lncRNA | ||||
CASC21 | ↓ | colorectal cancer | [73] | |
RHPN1-AS1 | ↓ | colorectal cancer, hepatocellular carcinoma |
[74,77] | |
RP4 | ↓ | colorectal cancer | [75] | |
TINCR | ↓ | colorectal cancer | [76] | |
KCNQ1OT1 | ↓ | hepatocellular carcinoma | [78] | |
LINC00115 | ↓ | triple-negative breast cancer, lung adenocarcinoma | [79,80] | |
MEG3 | ↓ | renal cell carcinoma | [81] | |
HOTAIR | ↓ | breast cancer | [82] | |
FOXD2-AS1 | ↓ | thyroid cancer | [83] | |
SOX21 - AS1 | ↓ | cervical cancer | [84] | |
UCA1 | ↓ | gastric cancer | [85] | |
ANRIL | ↓ | acute lymphoblastic leukemia | [86] | |
Cyrano | ↓ | brain | [87] |
↑, upregulation; ↓, downregulation.