Table 2.

MiRNA-7 in cancer treatment.

Tumor Type	MiR-7 Level	Drug	Role	Protein	Reference
Breast cancer	down	cisplatin	sensitize	REGγ, Bax/Bcl-2, cleaved Caspase-3	[130]
	down	cisplatin	sensitize	MRP1	[131]
	down	doxorubicin	sensitize	Raf-1, MAPK/ERK pathway	[65,66]
	down	doxorubicin	sensitize	EGFR/PI3K pathway	[132]
	up	tamoxifen	resistance	nd	[133]
	up	n.eo-adjuvant therapy: epirubicin, paclitaxel, cyclophosphamide, docextaxel; post-surgery: cyclophosphamide, fluorouracil, methotrexate	resistance	nd	[134]
	down	paclitaxel, carboplatin	sensitize	MRP1, Bcl-2	[135]
	down	trastuzumab	sensitize	EGFR	[136]
	down	lapatinib	sensitize	Raf-1/MAPK/Ap-1 pathway	[137]
Lung cancer	down	gefitinib	sensitize	EGFR	[141]
	down	gefitinib	sensitize	IGF-1R, PI3K, p-AKT, p-ERK	[142]
	up	gefitinib	resistance	nd	[143]
	down	cisplatin	sensitize	Bcl-2	[144]
	down	docetaxel	sensitize	nd	[145]
	down	paclitaxel	sensitize	EGFR	[146]
	down	nd	sensitize	MRP1	[147]
	down	cisplatin, doxorubicin, etoposide	sensitize	Kir2.1	[149]
	down	doxorubicin	sensitize	PARP1, BCRA1, Rad51	[150]
Glioblastoma	down	temozolomid	sensitize	YY1	[153]
	down	temozolomid, doxorubicin, carmustine	sensitize	MRP1, MRP6, P-gp, BCRP	[92]
Thyroid cancer	down	temozolomid, doxorubicin	sensitize	MRP1, MRP6, P-gp, BCRP	[92]
Cervical cancer	down	temozolomid, doxorubicin	sensitize	MRP1, MRP6, P-gp, BCRP	[92]
	down/up	cisplatin	resistance	PARP1, Bcl-2	[160]
Hepatocellular carcinoma	down	sorafenib	sensitize	TYRO3	[155]
	down	oxalipatin	sensitize	MRP1	[78]
Ovarian cancer	down	paclitaxel	sensitize	EGFR/ERK pathway	[157]
	down	cisplatin	sensitize	MAFG	[158]
Gastric cancer	down	cisplatin	sensitize	mTOR	[160]
Prostate cancer	down	docetaxel	sensitize	P-gp, Bcl-2, cycline D1	[68]
Chronic myeloid leukemia	up	imatinib	sensitize	BCR-ABL, PI3K/AKT pathway	[161]
Colorectal cancer	down	cetuximab	sensitize	EGFR, Raf-1, p-AKT, p-ERK	[113]
Melanoma	down	vemurafenib	sensitize	EGFR, Raf-1, p-AKT, p-ERK, IGF-1R, p-MEK	[162]
Pancreatic ductal adenocarcinoma	down	gemcitabine	sensitize	nd	[105]

nd, not defined.