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. 2021 Feb 11;13(2):282. doi: 10.3390/v13020282

Figure 1.

Figure 1

Berberine and obatoclax are effective antiviral compounds against Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Vero E6 cells were infected with SARS-CoV-2 (BavPat1 isolate) at an MOI of 0.01 for 24 h in the presence of the indicated concentrations of (A) berberine (BBR) or (B) obatoclax (OLX) in a two-fold dilution series or 0.1% DMSO as a control. Infectious viral titers from duplicate cell culture supernatants were assessed by plaque assay and plotted as percentage inhibition compared to the DMSO control. Error bars indicate SD. Dashed lines indicate 50% inhibition. A representative of two independent experiments is shown. Vero E6 cells were treated with the indicated concentrations of (C) berberine or (D) obatoclax or 0.1% DMSO. 24 h post-treatment, ATP content in cells from triplicate wells was measured as indication for cell viability, plotted as percentage compared to the DMSO control. Error bars indicate SD. A representative of two independent experiments is shown. The shaded grey box indicates that different OLX concentrations were used for antiviral (B) and viability assays (D).