Table 1.
Pathways of interest with genes differentially expressed in NSC-34 expressing superoxide dismutase 1 wild type (SOD1)WT in presence of 1 mM H2O2 for 3 h (p < 0.05, fold change ≥ 1.3).
| Gene Symbol | Gene Name | Fold Change | ||
|---|---|---|---|---|
| Cellular response to DNA damage stimulus | ||||
| Cep164 | centrosomal protein 164 | −1.80 | ||
| E2f7 | E2F transcription factor 7 | −1.35 | ||
| Ube2b | Ubiquitin-conjugating enzyme E2B | 1.31 | ||
| Rbx1 | ring-box 1 | 1.35 | ||
| Brip1 | BRCA1 interacting protein C-terminal helicase 1 | 1.36 | ||
| Pcna | proliferating cell nuclear antigen | 1.37 | ||
| Fancl | Fanconi anemia, complementation group L | 1.47 | ||
| Gtf2h1 | general transcription factor II H, polypeptide 1 | 1.56 | ||
| Apoptotic process | ||||
| Myc | myelocytomatosis oncogene | −2.83 | ||
| Tia1 | cytotoxic granule-associated RNA binding protein 1 | −2.53 | ||
| Pde5a | phosphodiesterase 5A, cGMP-specific | −2.21 | ||
| Mkl1 | MKL (megakaryoblastic leukemia)/myocardin-like 1 | −1.82 | ||
| Bik | BCL2-interacting killer | −1.71 | ||
| Dusp1 | dual specificity phosphatase 1 | −1.65 | ||
| Pim1 | proviral integration site 1 | −1.46 | ||
| Senp1 | SUMO1/sentrin specific peptidase 1 | −1.34 | ||
| Ube2b | Ubiquitin-conjugating enzyme E2B | 1.31 | ||
| Tm2d1 | TM2 domain containing 1 | 1.38 | ||
| Birc5 | baculoviral IAP repeat-containing 5 | 1.41 | ||
| Mad2l1 | MAD2 mitotic arrest deficient-like 1 | 1.43 | ||
| Cfdp1 | craniofacial development protein 1 | 1.56 | ||
| Cycs | cytochrome c, somatic | 1.58 | ||
| Mt1 | metallothionein 1 | 7.51 | ||
| Antioxidant response | ||||
| Pdia2 | protein disulfide isomerase associated 2 | −2.71 | ||
| Mtf1 | metal response element binding transcription factor 1 | −1.63 | ||
| Synaptic functions | ||||
| Sipa1l1 | signal-induced proliferation-associated 1 like 1 | −1.81 | ||
| Btbd9 | BTB (POZ) domain containing 9 | −1.79 | ||
| Apba1 | amyloid beta (A4) precursor protein binding. family A, member 1 | −1.79 | ||
| Nat8l | N-acetyltransferase 8-like | −1.65 | ||
| Pacsin1 | protein kinase C and casein kinase substrate in neurons 1 | −1.34 | ||
| Paip2 | polyadenylate-binding protein-interacting protein 2 | 1.55 | ||
| Cnn3 | calponin 3, acidic | 2.25 | ||
| Mitochondrial function | ||||
| Bik | BCL2-interacting killer | −1.71 | ||
| Alas1 | aminolevulinic acid synthase 1 | −1.43 | ||
| Slmo2 | slowmo homolog 2 (Drosophila) | 1.32 | ||
| Trit1 | tRNA isopentenyltransferase 1 | 1.35 | ||
| Metap1d | methionyl aminopeptidase type 1D (mitochondrial) | 1.36 | ||
| Lypla1 | lysophospholipase 1 | 1.38 | ||
| Hibadh | 3-hydroxyisobutyrate dehydrogenase | 1.38 | ||
| Mrpl9 | mitochondrial ribosomal protein L9 | 1.41 | ||
| Pgam5 | phosphoglycerate mutase family member 5 | 1.42 | ||
| Timm8a1 | translocase of inner mitochondrial membrane 8A1 | 1.49 | ||
| Ndufab1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 | 1.54 | ||
| Lyrm7 | LYR motif containing 7 | 2.03 | ||
| Endosome and golgi functions | ||||
| Adcy6 | adenylate cyclase 6 | −1.53 | ||
| Rab21 | RAB21, member RAS oncogene family | −1.35 | ||
| Rab9 | RAB9, member RAS oncogene family | 1.33 | ||
| Pmel | premelanosome protein | 1.50 | ||
| Arl1 | ADP-ribosylation factor-like 1 | 1.52 | ||