Table 3.
Gene Set Enrichment Analysis (GSEA) querying Hallmark database of DE target genes in melanoma patients expressing high miRNA-181a and -181b versus low.
| GENE SET | pval | padj | ES | NES |
|---|---|---|---|---|
| E2F_TARGETS | 0.025 | 0.067476383 | −0.645120028 | −2.362223392 |
| MYC_TARGETS_V1 | 0.025641026 | 0.067476383 | −0.578931346 | −2.098724203 |
| MYC_TARGETS_V2 | 0.005263158 | 0.029239766 | −0.653683002 | −2.054477496 |
| G2M_CHECKPOINT | 0.025641026 | 0.067476383 | −0.53100629 | −1.925856679 |
| UNFOLDED_PROTEIN_RESPONSE | 0.010204082 | 0.051020408 | −0.543515092 | −1.895494756 |
| MTORC1_SIGNALING | 0.025 | 0.067476383 | −0.493595313 | −1.804927713 |
| DNA_REPAIR | 0.015151515 | 0.067476383 | −0.472340422 | −1.677943319 |
| GLYCOLYSIS | 0.023255814 | 0.067476383 | −0.443156625 | −1.576560747 |
| OXIDATIVE_PHOSPHORYLATION | 0.023255814 | 0.067476383 | −0.436113647 | −1.557784166 |
| HEDGEHOG_SIGNALING | 0.03930131 | 0.098253275 | −0.545687766 | −1.479472244 |
| APOPTOSIS | 0.050437567 | 0.153125145 | 0.480331268 | 1.267604291 |
| ROS_PATHWAY | 0.084367246 | 0.162244703 | 0.559128155 | 1.311901032 |
| P53_PATHWAY | 0.003115265 | 0.019778481 | 0.529555328 | 1.416399563 |
| IL2_STAT5_SIGNALING | 0.002089864 | 0.018705574 | 0.548857874 | 1.463005267 |
| IL6_JAK_STAT3_SIGNALING | 0.001157407 | 0.014467593 | 0.649692129 | 1.607476866 |
| IFNγ_RESPONSE | 0.001042753 | 0.014467593 | 0.628035534 | 1.675781046 |
| IFNα_RESPONSE | 0.002244669 | 0.018705574 | 0.627922857 | 1.596308497 |