Figure 5.

(A). Sham castrated or castrated TRAMP mice received water control (n = 10 each for sham or castrated group) or 25 or 150 mg/kg 2-ME₂ (n = 10 each for sham or castrated group per respective dose). The experiment was terminated following 10 week-intervention and prostate tumor, or tissue was collected for histopathological evaluation. A representative image of H&E staining is shown. (B) Box plots showing levels of indicated bile acids in serum from castrated or sham-castrated mice (n = 5 per each group).