Figure 1.

The emerging cancer ecosystem in myeloproliferative neoplasms (MPNs). Several cellular players contribute to the MPN-associated microenvironment, characterized by increased cytokine signaling, fibrosis, inflammation-driven immunosuppression and immune escape. MSCs: mesenchymal stem cells, MDSCs: myeloid-derived suppressor cells, APCs: antigen-presenting cells, TCR: T cell receptor, Th: T helper, NK: natural killer, ILCs: innate lymphoid cells, Tregs: T regulatory cells, ⊥: inhibition, X: block.