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Table 4.

Leukemia-free survival by risk group in the training and validation subsets

Training subset Validation subset Brier score*
Risk group n HR (95% CI) P n HR (95% CI) P
AML
 Low 34 1.00 <.0001 29 1.00 <.0001
 Intermediate 291 1.91 (0.93-3.91) .0764 308 3.05 (1.25-7.45) .0114
 High 144 3.22 (1.56-6.662) .0016 138 4.87 (1.97-12.02) .0006
 Very high 93 5.65 (2.72-11.73) <.0001 92 8.10 (3.26-20.11) <.0001
ALL
 Low 238 1.00 <.0001 227 1.00 <.0001
 Intermediate 364 1.56 (1.19-2.04) .0014 379 1.72 (1.29-2.28) .0002
 High 42 2.90 (1.88-4.48) <.0001 30 3.55 (2.15-5.85) <.0001

n, number evaluable.

*

AML, 0.154; ALL, 0.152.