Table 2.
Most common AEs grade 2 or higher
| AE* | HD cohort | LD cohort | Total | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Grade | Total | Grade | Total | |||||||
| 2 | 3 | 4 | 2 | 3 | 4 | 5 | ||||
| Lymphocytopenia | 7 | 6 | 1 | 14 | 3 | 5 | 1 | — | 9 | 23 |
| Upper respiratory tract infection | 7 | — | — | 7 | 14 | — | — | — | 14 | 21 |
| Pneumonia | 5 | 2 | — | 7 | 4 | 4 | — | 1 | 9 | 16 |
| Hypophosphatemia | 6 | 4 | — | 10 | 4 | 1 | — | — | 5 | 15 |
| Fatigue† | 5 | 5 | — | 10 | 2 | 1 | — | — | 3 | 13 |
| Maculopapular rash† | 4 | 1 | — | 5 | 7 | 1 | — | — | 8 | 13 |
| Skin infection | 4 | 1 | — | 5 | 1 | 5 | — | — | 6 | 11 |
| Neutropenia | 6 | 2 | 1 | 9 | 2 | — | — | — | 2 | 11 |
| Anemia | 2 | 2 | — | 4 | 4 | — | — | — | 4 | 8 |
| Limb edema | 2 | 1 | — | 3 | 4 | — | — | — | 4 | 7 |
| Hypotension | 1 | 1 | — | 2 | 2 | 1 | 1 | — | 4 | 6 |
| Skin ulceration† | 1 | — | — | 1 | 2 | 3 | — | — | 5 | 6 |
| Increased alanine aminotransferase† | 2 | 1 | 1 | 4 | 2 | — | — | — | 2 | 6 |
| Diarrhea† | 2 | 2 | — | 4 | 2 | — | — | — | 2 | 6 |
| Tremor | 5 | — | — | 5 | 1 | — | — | — | 1 | 6 |
| Hypertension | 1 | 1 | — | 2 | 3 | — | — | — | 3 | 5 |
| Leukocytopenia | 2 | 1 | — | 3 | 2 | — | — | — | 2 | 5 |
| Hypoalbuminemia | 2 | — | — | 2 | 3 | — | — | — | 3 | 5 |
| Myalgia/muscle cramps† | 4 | — | — | 4 | 1 | — | — | — | 1 | 5 |
| Nausea† | 3 | — | — | 3 | 2 | — | — | — | 2 | 5 |
*
The data cutoff was March 22, 2017. Multiple occurrences of the same AE in 1 subject were counted every time for corresponding grade.
†
AEs possibly related to cGVHD.