Table 1.

Multifunctional nanoparticles-based treatment of melanoma reported in the last three years (2018–2020).

Nanocarrier	Anticancer Agent	Functionalization	Ref
Liposome	Anacardic acid, Mitoxantrone, Ammonium ascorbate, PTX, TRAIL, Vemurafenib, Hypericin, n-Butylidenephthalide, Hydroxychloroquine, eIF3i shRNA, Hispolon, and 5-fluorouracil.	Stearyl chain (C18) fused pH-sensitive cell-penetrating peptide (C18-TR), Peptide: TD (ACSSSPSKHCG), DPPC, R8-dGR peptide, iRGD.	[82,83,84,85,86,87,88]
Polymeric nanoparticles	Indocyanine green, Pyrazoline, Dox, Gadopentetic acid, PTX, Ellagic acid, Curcumin, Antigenic peptide (hgp10025-33), and TLR 4 agonist.	Proteins, Chitosan, Cyclodextrin and Starch, PLGA, RBC.	[89,90,91,92]
Dendrimer	Cytosine–phosphate–guanine oligonucleotides and DOX.	PEG-PAMAM, LMWH.	[93,94]
Carbon nanoparticles	-	Fluorescent nitrogen–phosphorous-doped carbon dots.	[95]
Metal nanoparticles	Dacarbazine, Mesilato de imatiniband siRNA STAT-3 and Cas9-sgPlk-1 plasmids.	Magnetic nanoparticles, Gold nanoparticles, and Silica nanoparticles.	[96,97,98]

PTX, Paclitaxel; TRAIL: Tumor necrosis factor (tnf)-related apoptosis inducing ligand; eIF3i: Eukaryotic translation initiation factors 3i; DOX: Doxorubicin; TLR: Toll-like receptor; STAT-3: Signal Transducer and Activation of Transcription 3 factor; DPPC: Dipalmitoylphosphatidylcholine; iRGD: internalizing RGD peptide; PLGA: Poly (d, l-lactic-coglycolic acid); RBC: Erythrocyte (RBC); PAMAM: Poly(ethylene glycol)-polyamidoamine; LMWH: Low-molecular-weight heparin.