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. 2021 Feb 11;14(2):145. doi: 10.3390/ph14020145

Table 1.

Summary of the 2020 FDA peptides and oligonucleotides (TIDES) harvest.

# Active Ingredient (Trade Name) Type Indication Target Route
1 Viltolarsen (ViltepsoTM) Antisense
oligonucleotide
Duchenne’s muscular dystrophy (DMD) DMD Exon 53 Intravenous
2 Lumasiran
(OxlumoTM)
Antisense
oligonucleotide
Primary
hyperoxaluria type 1 (PH1)
Hydroxyacid oxidase (glycolate oxidase) 1 (HOA1) mRNA Subcutaneous
3 Setmelanotide (ImcivreeTM) Peptide Chronic weight
management (obesity)
Melanocortin-4
receptor (MC4R)
Subcutaneous
4 64Cu-DOTATATE (DetectnetTM) Peptide Scintigraphic imaging Somatostatin receptor Intravenous
5 68Ga-PSMA-11 Peptide Diagnosis of recurrent prostate carcinoma Prostate-specific
membrane antigen (PSMA)
Intravenous
6 Belantamab mafodotin-blmf (BlenrepTM) ADC a with peptide payload Relapsed or refractory multiple myeloma B-cell maturation
antigen (BCMA)
Intravenous

a ADC, antibody drug conjugate.