Table 4.

Relationships between the expression of 20 CRC study genes and clinical and pathological characteristics of patients.

Gene Symbol	Fold Change of Stage			Fold Change of Lymph Node Metastasis			Fold Change of Tumor Site			Fold Change of Differentiation Grade
	I, II	ΙIΙ, IV	p-Value	Yes	No	p-Value	Right	Left	p-Value	Well	Poor	p-Value
VANGL1	3.795 ± 5.63	8.831 ± 11.80	0.05	9.749 ± 12.40	4.136 ± 6.38	0.02	7.144 ± 10.44	5.243 ± 8.23	0.26	6.516 ± 9.22	4.831 ± 10.50	0.07
IL2RA	1.073 ± 1.59	1.188 ± 1.44	0.40	0.982 ± 1.19	1.214 ± 1.68	0.85	1.293 ± 1.84	0.957 ± 1.08	0.63	1.221 ± 1.56	0.707 ± 1.23	0.12
IL2RB	0.728 ± 1.31	0.591 ± 1.02	0.64	0.433 ± 0.43	0.797 ± 1.33	0.19	0.520 ± 0.85	0.811 ± 1.44	0.78	0.618 ± 1.21	0.864 ± 1.00	0.05
TGFβ	0.977 ± 1.50	1.418 ± 2.17	0.71	1.560 ± 2.25	0.971 ± 1.56	0.22	1.086 ± 1.66	1.296 ± 2.06	0.53	1.649 ± 1.84	1.088 ± 1.90	0.26
SMAD2	1.257 ± 2.13	0.821 ± 1.37	0.27	0.702 ± 1.26	1.250 ± 2.05	0.19	1.053 ± 2.17	1.043 ± 1.36	0.24	0.371 ± 1.95	1.196 ± 0.65	0.04
SMAD4	2.483 ± 2.50	2.128 ± 1.99	0.78	2.096 ± 1.99	2.440 ± 2.41	0.82	2.165 ± 2.41	2.467 ± 2.11	0.37	2.068 ± 2.20	2.367 ± 2.60	0.22
CD44	0.480 ± 0.61	0.650 ± 1.03	0.77	0.767 ± 1.14	0.441 ± 0.58	0.65	0.705 ± 1.03	0.413 ± 0.55	0.24	0.570 ± 0.76	0.522 ± 1.15	0.35
CD133	0.842 ± 1.99	1.421 ± 2.85	0.63	1.324 ± 2.43	1.000 ± 2.46	0.50	0.831 ± 1.59	1.421 ± 3.08	0.45	1.204 ± 2.63	0.738 ± 1.21	0.26
HES1	2.111 ± 2.96	2.767 ± 3.80	0.44	2.944 ± 4.06	2.123 ± 2.91	0.33	2.707 ± 3.90	2.134 ± 2.76	0.29	2.637 ± 3.58	1.465 ± 2.11	0.47
NOTCH1	1.147 ± 2.44	0.861 ± 1.90	0.66	0.968 ± 2.10	1.034 ± 2.26	0.87	0.768 ± 1.49	1.261 ± 2.73	0.16	1.170 ± 2.38	0.278 ± 0.49	0.13
LEF1	0.844 ± 0.87	1.371 ± 1.89	0.76	1.424 ± 1.99	0.905 ± 1.02	0.67	0.980 ± 1.49	1.218 ± 1.45	0.21	1.056 ± 1.34	1.283 ± 2.00	0.51
MTA1	0.983 ± 0.98	1.072 ± 1.00	0.72	1.073 ± 1.03	0.998 ± 0.96	0.83	1.178 ± 0.97	0.868 ± 0.99	0.08	1.024 ± 0.98	1.032 ± 1.04	0.89
EGFR	2.693 ± 3.86	2.620 ± 4.02	0.84	2.091 ± 2.65	2.990 ± 4.49	0.56	3.214 ± 4.31	2.078 ± 3.40	0.22	2.595 ± 4.12	2.945 ± 2.91	0.33
MAP2K1	1.442 ± 2.57	1.436 ± 2.07	0.33	1.549 ± 1.25	1.253 ± 2.58	0.98	1.251 ± 2.09	1.636 ± 2.57	0.34	1.377 ± 2.34	1.724 ± 2.34	0.39
FOLH1	0.857 ± 0.90	0.753 ± 0.75	0.55	0.767 ± 0.76	0.831 ± 0.87	0.79	0.848 ± 0.90	0.764 ± 0.75	0.70	0.829 ± 0.86	0.708 ± 0.67	0.83
BUB1	0.607 ± 1.35	0.652 ± 1.73	0.95	0.617 ± 1.67	0.636 ± 1.47	0.96	0.559 ± 1.28	0.702 ± 1.78	0.65	0.695 ± 1.68	0.328 ± 0.48	0.27
RHOA	0.294 ± 0.39	0.807 ± 1.32	0.21	0.916 ± 1.46	0.320 ± 0.43	0.24	0.645 ± 1.13	0.431 ± 0.81	0.36	0.501 ± 0.86	0.720 ± 1.44	0.78
PCSK7	4.290 ± 5.74	4.827 ± 6.81	0.12	4.170 ± 5.51	4.770 ± 6.21	0.19	3.614 ± 4.51	5.520 ± 6.32	0.07	4.364 ± 5.65	5.384 ± 6.96	1.00
PITX2	0.644 ± 1.03	0.957 ± 1.95	0.98	1.079 ± 2.16	0.627 ± 1.03	0.63	0.959 ± 1.98	0.622 ± 0.92	0.84	0.737 ± 1.12	1.056 ± 2.82	0.21
ANXA3	3.320 ± 4.54	4.811 ± 7.06	0.67	5.542 ± 7.75	3.150 ± 4.31	0.21	4.597 ± 7.06	3.450 ± 4.39	0.73	7.065 ± 4.91	3.370 ± 8.71	0.01