Figure 14.

(A) Schematic configurations of bis-Zn²⁺-pyridyl salen modified ATP aptamers acting as nucleoapzymes for the catalyzed hydrolysis of ATP to ADP. (B) Rates of ATP hydrolysis to ADP by representative nucleoapzymes: a = nucleoapzyme in configuration III; b = nucleoapzyme in configuration IV; c = control experiment using the separated bis-Zn²⁺-pyridyl salen catalyst and the ATP aptamer. (C) Molecular dynamics energy-minimized structures of the nucleoapzyme in: Configuration III (I) and in Configuration IV (II). Reproduced with permission from ref. [177]. Copyright 2020 Wiley-VCH.