Table 2.

List of hypoxia-responsive long non-coding RNAs involved in cell proliferation, apoptosis and cell cycle regulation.

lncRNAs	Cancer Types	Regulation Hypoxia-Mediated	Regulatory Mechanism	Targets	Functions	References
H19	colorectal cancer, glioblastoma, non-small cell lung cancer and lung cancer	upregulation	direct transcriptional activation or indirect SP1-mediated transcriptional activation	NA	mediates cancer cell proliferation upregulates cell viability	[79,93,94,95,96]
HOTAIR	NSCLC, breast, cervical and endometrial cancer	upregulation	transcriptional activation	JAM2, PCDH10, PCDHB5	upregulates cell viability	[97,98,99,100]
UCA1	urinary bladder cancer	upregulation	transcriptional activation	BAX	mediates cancer cell proliferation	[101]
MALAT1	hepatocellular carcinoma	upregulation	transcriptional activation	miR-200a	upregulates cell proliferation	[102]
	lung adenocarcinoma cells	upregulation	transcriptional activation	PTB-associated splicing factor protein (PSF)	promotes proliferation	[103]
	myeloma cells	upregulation	transcriptional activation	MALAT1 itself through the regulation of the KDM3A (H3K9 demethylating enzyme)	upregulates cell proliferation	[104]
NEAT1	NSCLC	upregulation	transcriptional activation	miR-101-3p	increases cell proliferation	[105]
LUCAT1	colorectal cancer	upregulation	transcriptional activation	PTBP1	induces apoptosis resistance, prolonging G2/M phase	[106]
AGAP2-AS1	gastric cancer and HCC	upregulation	transcriptional activation	miR-16-5p	promotes cell proliferation and inhibits apoptosis	[107]
PVT1	lung cancer cells, nasopharyngeal carcinoma	upregulation	NA	NA	induces cell proliferation	[108,109]
HIF1A-AS2	breast cancer cells and tumour	upregulation	transcriptional activation	miR-548c-3p	induces cell proliferation	[110]
LET	gallbladder cancer cells	downregulation	NA	NA	induces cell viability and proliferation	[111]
Hincut 1	colorectal/breast cancer cells	upregulation	transcriptional activation	NA	upregulates proliferation	[112]
Linc-ROR	liver cancer cells	upregulation		miR-145	promotes cell survival	[113]
BX111	pancreatic cancer	upregulation	transcriptional activation	ZEB1	promotes cell proliferation	[114]
FALEC	prostate cancer	upregulation	transcriptional activation		promotes cell proliferation	[115]
NUTF2P3-001	pancreatic cancer	upregulation	transcriptional activation	NA	promotes cell viability and proliferation	[116]