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. 2021 Feb 14;9(2):190. doi: 10.3390/biomedicines9020190

Figure 5.

Figure 5

The role of the NLRP3-ASC inflammasome in tau pathogenesis. Either fibrillary Aβ or tau species in the form of monomers or oligomers are sufficient to induce the assembly of the NLRP3 inflammasome, consisting of NLRP3, ASC, and pro-caspase 1, which further leads to caspase 1-dependent release of the pro-inflammatory cytokines IL-1β and IL-18 [85]. The activation of the NLRP3 inflammasome in microglia has been demonstrated to promote neuronal tau hyperphosphorylation in an IL-1 receptor-dependent manner via the regulation of multiple tau kinases, like GSK-3β and CaMKII-α.