Table 1.
Antiprotozoal activity and cytotoxicity of isolated compounds of H. afrum.
| Compounds Codes |
Compounds Names | L. Donovani Promastigote IC50 (μM) | L. Donovani Promastigote IC90 (μM) |
L. Donovani Amastigote IC50 (μM) |
L. Donovani Amastigote IC90 (μM) |
L. Donovani Amastigote/THP1 IC50 (μM) | L. Donovani Amastigote/THP1 IC90 (μM) |
T. Brucei IC50 (μM) |
T. Brucei IC90 (μM) |
THP1 Cytotoxicity IC50 (μM) | THP1 Cytotoxicity IC90 (μM) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| AMB | Amphotericin | 0.136 | 0.215 | 0.211 | 0.374 | 0.188 | 0.421 | NT | NT | >2 | >2 |
| PENT | Pentamidine | 1.478 | 2.382 | 9.581 | >10 | 1.157 | 5.587 | 0.001 | 0.002 | >10 | >10 |
| DFMO | difluoromethylornithine | NT | NT | NT | NT | NT | NT | 3.634 | 8.804 | NT | NT |
| 1 | Quercetin | >10 | >10 | >10 | >10 | >10 | >10 | 7.52 | 9.76 | >10 | >10 |
| 2 | Miricitrin | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
| 3 | Biapigenin | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
| 4 | Myricetin | >10 | >10 | >10 | >10 | >10 | >10 | 5.71 | 7.97 | >10 | >10 |
| 5 | Hyperoside | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
| 6 | Myricetin-3-O-β-d-glucopyranoside | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
| 7 | Cannabiscitrin | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 | >10 |
NT, not tested; IC-50 and IC-90 values are expressed as µM and are the mean ±S.D. of duplicate observations. Tested concentrations range: 0.4–10 ug/mL.