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Targeting key signaling pathways in patients with pancreatic ductal adenocarcinoma (PCa). EGFR, epidermal growth factor receptor; RAS, rat sarcoma viral oncogene; AKT, protein kinase B; CDK4/CDK6, cyclin-dependent kinase 4/6; RAF, rapidly accelerated fibrosarcoma; MEK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinases; PI3K, phosphoinositide 3-kinase; mTOR, mechanistic target of rapamycin; FAK, focal adhesion kinase; BTK, Bruton’s tyrosine kinase.
