Table 1.
Patient characteristics
|
|
irAE
|
||||||
|
Overall
|
Yes
|
No
|
|||||
|
n
|
%
|
n
|
%
|
n
|
%
|
||
| Gender | 0.8120 | ||||||
| Female | 129 | 44.0 | 41 | 45.1 | 88 | 43.6 | |
| Male | 164 | 56.0 | 50 | 54.9 | 114 | 56.4 | |
| Race | 0.0141 | ||||||
| White | 140 | 47.8 | 55 | 60.4 | 85 | 42.1 | |
| Black | 122 | 41.6 | 28 | 30.8 | 94 | 46.5 | |
| Asian | 13 | 4.4 | 4 | 4.4 | 9 | 4.5 | |
| Hispanic | 2 | 0.7 | 0 | 0 | 2 | 1.0 | |
| Native American | 1 | 0.3 | 1 | 1.1 | 0 | 0 | |
| Other | 11 | 3.8 | 1 | 1.1 | 10 | 5.0 | |
| Unknown | 4 | 1.4 | 2 | 2.2 | 2 | 1.0 | |
| Death | 0.1488 | ||||||
| No | 131 | 44.7 | 35 | 38.5 | 96 | 47.5 | |
| Yes | 162 | 55.3 | 56 | 61.5 | 106 | 52.5 | |
| PDL1 positive | 0.0695 | ||||||
| Yes | 71 | 24.2 | 25 | 27.5 | 46 | 22.8 | |
| No | 70 | 23.9 | 15 | 16.5 | 55 | 27.2 | |
| Missing | 152 | 51.9 | 51 | 56.0 | 101 | 50.0 | |
| PDL1 expression | 0.0354 | ||||||
| < 50% | 69 | 23.5 | 16 | 17.6 | 53 | 26.2 | |
| ≥ 50% | 32 | 10.9 | 14 | 15.4 | 18 | 8.9 | |
| Missing | 192 | 65.5 | 61 | 67.0 | 131 | 64.9 | |
| Line of therapy | 0.9432 | ||||||
| 1 | 85 | 29.0 | 29 | 31.9 | 56 | 27.7 | |
| 2 | 130 | 44.4 | 37 | 40.7 | 93 | 46.0 | |
| 3 | 35 | 11.9 | 12 | 13.2 | 23 | 11.4 | |
| 4 | 17 | 5.8 | 5 | 5.5 | 12 | 5.9 | |
| 5 | 8 | 2.7 | 2 | 2.2 | 6 | 3.0 | |
| 6 | 2 | 0.7 | 1 | 1.1 | 1 | 0.5 | |
| 7 | 2 | 0.7 | 0 | 0 | 2 | 1.0 | |
| 8 | 1 | 0.3 | 0 | 0 | 1 | 0.5 | |
| Missing | 13 | 4.4 | 5 | 5.5 | 8 | 4.0 | |
| Progression | 0.0140 | ||||||
| Yes | 121 | 41.3 | 28 | 30.8 | 93 | 46.0 | |
| No | 172 | 58.7 | 63 | 69.2 | 109 | 54.0 | |
irAE: Immune-related adverse events; PDL1: Programmed death ligand 1.