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Schematic representation of antagonistic functional effects driven by decorin on the IGF system. In tumor stroma, decorin binds the ligands IGF1, IGF2 and insulin as well as the receptors IGF1R and IR-A. Decorin inhibits ligand-mediated IGF1R phosphorylation while it enhances IGF-2-mediated IR-A protein degradation. Negative decorin action on downstream pathways is reported.
