Table 1.
Selected Compounds and References.
| Compound | Clinical or Intended Use | MOA | Group | Reference |
|---|---|---|---|---|
| AT7519 | Cancer treatment | CDK Inhibitor | Investigational | [12] |
| Bortezomib | Cancer treatment | Proteosome Inhibitor | Approved | [13] |
| BS-194 | Cancer treatment | CDK Inhibitor | Investigational | [12] |
| Clofazimine | Leprosy treatment | Precise Mechanism Unknown | Approved | [13] |
| Cyclosporine A | Prophylaxis of organ transplant rejection | Calcineurin Inhibitor | Approved | [13] |
| Dactinomycin | Cancer treatment | DNA Topoisomerase Inhibitor | Approved | [13] |
| Daptomycin | Treatment of skin infections | Destabilization of Bacterial Cell Membrane | Approved | [13] |
| Deferasirox | Treatment of chronic iron overload | Iron Chelator | Approved | [13] |
| Dinaciclib | Cancer treatment | CDK Inhibitor | Investigational | [12] |
| Emricasan | Treatment of Hepatitis, liver disease, and organ transplantation | Caspase Inhibitor | Investigational | [12] |
| Fingolimod | Multiple sclerosis | Sphingosine-1-phosphate Receptor Modulator | Approved | [13] |
| Flavopiridol | Cancer treatment | CDK Inhibitor | Investigational | [12] |
| Gemcitabine | Cancer treatment | Thymidylate Synthetase Inhibitor | Approved | [13] |
| Ivermectin | Broad-spectrum anti-parasite medication | Agonist of Chloride Ion Channels in Invertebrates | Approved | [13] |
| Mefloquine | Treatment of Malaria | Precise Mechanism Unknown | Approved | [13] |
| Mercaptopurine | Cancer treatment | Hypoxanthine-guanine Phosphoribosyltransferase Inhibitor | Approved | [13] |
| Methoxsalen | Treatment of psoriasis and vitiligo | DNA Intercalation | Approved | [13] |
| Micafungin | Treatment of fungal infections | Inhibits the synthesis of beta-1,3-D-glucan | Approved | [13] |
| Mycophenolate Mofetil | Prophylaxis of organ transplant rejection | Inosine 5’-Monophosphate Dehydrogenase Inhibitor | Approved | [13] |
| Mycophenolic Acid | Prophylaxis of organ transplant rejection | Inosine 5’-Monophosphate Dehydrogenase Inhibitor | Approved | [13] |
| Palonosetron | Prevention of acute nausea and vomiting from chemotherapy | 5-Hydroxytryptamine Receptor Antagonist | Approved | [13] |
| PHA-690509 | Cancer treatment | CDK Inhibitor | Investigational | [12] |
| PHA-793887 | Cancer treatment | CDK Inhibitor | Investigational | [12] |
| Pyrimethamine | Treatment of Malaria and Toxoplasmosis | Dihydrofolate Reductase Inhibitor | Approved | [13] |
| RGB-286147 | Cancer treatment | CDK Inhibitor | Investigational | [12] |
| Roscovitine | Cancer treatment | CDK Inhibitor | Investigational | [12] |
| Sertraline | Antidepressant | Reuptake of Serotonin Inhibitor | Approved | [13] |
| SNS-032 | Cancer treatment | CDK Inhibitor | Investigational | [12] |
| Sorafenib Tosylate | Cancer treatment | Inhibits Several Intracellular and Cell Surface Kinases | Approved | [13] |