Table 2.
Summary of previously reported data concerning abnormal metabolism in patients with DM1.
| Patients Characteristics |
DM1 (n = 623) [27,28,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70] |
Controls (n = 428) [27,55,56,57,59,60,61,62,64,65,68,70] |
| Patients per study | 44 ± 33; (8–115) [27,28,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70] |
96.8 ± 203.3; (3–734) [27,55,56,57,59,60,61,62,64,65,68,70] |
| Age (years) | 41.7 ± 3.8; (34–47) [27,28,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70] |
42.35 ± 6.17; (33–54.6) [27,55,56,57,59,60,61,62,64,65,68,70] |
| Sex | 379 F, 417 M [27,28,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70] |
347 F, 815 M [27,55,56,57,59,60,61,62,64,65,68,70] |
| BMI (kg/m2) | 23.8 ± 1.75; (22.3–27.2); Median: 23.4 [27,28,55,57,58,59,61,63,64,65,66,67,70] |
23 ± 0.72; (21.7–23.7); Median: 23.2 [27,55,57,59,61,64,65,70] |
| Waist circumference (cm) | 95.8 ± 2.19; (94.3–97.4) Median: 93.43 [27,57,58,59] |
84.9; Median: 87.5 [27,57,59] |
| CTG repeat length | 555.22 ± 250.99; (355.9–973); Median: 413.75 [28,55,58,59,60,63,65,66,67,69,70] |
ND |
| Central Obesity (%) | 13.6 [63] |
ND |
| Metabolic syndrome (%) | 16.7–41.2 [58,63] |
ND |
| Insulin metabolism (pmol/L) | 125.4 ± 63.5; (51.38–186.11); Median: 73.5 Male: 127.8 ± 33.4; (104.26–151.45) Female: 119.8 ± 22,1; (104.16–135.48) [27,28,55,56,57,58,59,60,61,62] |
69.9 ± 28.4; (45.8–86.0); Median: 44.29 Male: 56.25 Female: 63 [27,57,59,60,61,62] |
| HOMA-IR | 3.03 ± 1.7; (1.9–6.4); Median: 2.25 Male: 4.7 Female: 3.7 [27,55,56,57,58,61,65,70] |
1.43 ± 0.13; (1.3–1.6); Median: 1.42 [27,57,61,65] |
| Glucose metabolism (mg/dL) | 91.84 ± 7.5; (82.7–108.5); Median: 91.4 Male: 90.5 ± 6.3; (86–95) Female: 95.9 ± 24.1; (78.9–113.0) [27,28,55,56,57,58,60,61,62,63,64,65,66,67] |
89.65 ± 5.11; (81.6–95.6); Median: 90 Male: 83 Female: 88 [27,55,57,60,61,62,64,65] |
| Total cholesterol (mg/dL) | 200.34 ± 15.88; (176–228); Median: 200 Male: 216.37 ± 50.02; (181.0–251.7) Female: 200.8 ± 13.9; (191.0–210.7) [27,28,55,56,57,58,59,60,62,63,64,65,67] |
179.4 ± 24.5; (146.0–200.5); Median: 176.72 Male: 128 Female: 134 [27,55,57,59,60,62,64,65] |
| HDL (mg/dL) | 52.42 ± 3.64; (48.2–58.0); Median: 51.4 Male: 44 Female: 61 [27,28,58,59,60,62,63,64,65,66,68,69] |
51.4 ± 5.5; (45.7–56.7 51.82); Median: 51.82 Male: 67 Female: 55 [27,53,57,58,61,62,65,66] |
| LDL (mg/dL) | 118.38 ± 14.65; (106.34–143.08); Median: 122.6 Male: 104 Female: 101 [27,28,58,59,60,62,63,64,68,69] |
110.0 ± 17.7; (97.4–122.6); Median: 129.3 Male: 146 Female: 102 [27,59,60,62,64,68,69] |
| TAG (mg/dL) | 184.9 ± 52.5; (108–274); Median: 172.4 Male: 194.3 ± 11.7; (186.0–202.6) Female: 134.1 ± 18.2; (121–147) [27,28,56,57,58,59,60,62,63,64,65,66,67,68,69] |
115.9 ± 39.6; (77–168); Median: 95.2 Male: 75 Female: 105 [27,57,59,60,62,64,65,68,69] |
Data expressed as mean ± SD (range). Abbreviations: NA—Not applicable; ND—Not Determined; F—Female; M—Male; BMI—Body Mass Index; HOMA-IR—Insulin resistance index HDL—High-density lipoprotein; LDL—Low-density lipoprotein; TAG—Triacylglycerol.