Table 2.

Possible biomarkers used for the detection of hepatocellular carcinoma (HCC).

Biomarker	Role in HCC Development
Osteopontin	Glycoprotein of the extracellular matrix, overly expressed in HCC
Dickkopf-1	Inhibitor of Wnt/β-catenin signaling, overly expressed in HCC
miR-122	Marker of liver injury; suppressed in HCC
GSTP1	Negatively correlated with tumor size and overall survival
RASSF1	Positively correlated with longer overall survival and better prognosis
LINE-1	Hypomethylation associated with shorter overall survival