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. 2021 Feb 24;220(5):e202007152. doi: 10.1083/jcb.202007152

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© 2021 Jones et al.

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Figure 2. — Motif analysis identifies ZNF416 as a putative regulator of fibroblast activation in vitro and in vivo. (a) De novo DNA motif enrichment analysis of differential chromatin accessibility loci of fibroblasts on soft versus stiff matrices ranked by P value. Percentage of targets indicates the percentage of total input sequences which contain that respective motif. (b) Schematic of approach to identify differentially expressed genes in mouse fibroblasts following bleomycin challenge to induce experimental lung fibrosis. De novo DNA motif enrichment analysis was done in the promoter region (±1 kb from the TSS) of each differentially expressed gene. P value describes a statistical measure of the enrichment of the DNA motif within the input genomic DNA sequences compared with randomly generated “background” sequences.