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. 2021 Feb 12;22(4):1825. doi: 10.3390/ijms22041825

Figure 5.

Figure 5

Effects of Rap1 inhibition on CXCL2-induced neutrophil chemotaxis in vitro. Data shown are the migration distance (µm), chemotaxis distance (µm), chemotaxis index, migration velocity (µm/min), and chemotaxis velocity (µm/min) for 60 min of neutrophils treated with DMSO (vehicle) or GGTI298 (10 µM)—a geranylgeranyltransferase I inhibitor for blocking the processing of geranylgeranylated Rap1—in 2D chemotaxis µ-slide (averaged from >50 cells). Mean ± SEM of 4 mice per group. ** and *** indicate significant differences (p < 0.01 and p < 0.001, respectively) from the WT neutrophils with DMSO only.