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Molecular Circadian Oscillator is formed as a transcriptional translational feedback loop. Transcription factors, BMAL1 and CLOCK, drive the transcription of clock genes: Pers, Crys, Rev-Erbs, Rors. PER and CRY proteins, in turn, heterodimerize and inhibit CLOCK/BMAL1 complex activity and their own transcription, which form one loop. Rev-Erbs and RORs form a second loop and act by either repressing or activating Bmal1 transcription.
