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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Representative ligands binding at the colchicine site used as a starting point for the rational design of new Microtubule Destabilizing Sulfonamides (MDS). General structure and structure variations of new MDS.