Table 1.

Definitions for Line of Treatment Ratings.

Line of Treatment	Evidence Level Criteria
First	Level 1 or Level 2 evidence for efficacy plus clinical support for safety/tolerability/feasibility
Second	Level 3 or higher evidence for efficacy plus clinical support for safety/tolerability/feasibility
Third	Level 4 evidence or higher for efficacy plus clinical support for safety/tolerability/feasibility
Not recommended	Level 1 evidence for lack of efficacy or Level 2 evidence for lack of efficacy plus expert consensus